“Weeding” Through the Controversy of Marijuana Pharmacology

1 04 2008

By Justin Brown | 01 April 2008

Introduction
In 1999, famed talk show host Montel Williams publicly announced that he had been diagnosed with degenerative Multiple Sclerosis. In November of 2003 he was stopped in a Detroit Michigan airport for possession of Marijuana. He was not charged because he reportedly proved that his physician had prescribed its use. Although Williams adequately defined his legal right to possess the prohibited plant, authorities still fined him for possession of the “paraphernalia” that allowed him to take his “medicine”.

Since the late 1950’s the public use of marijuana, has been at the forefront of American debate and anti-drug legislation. Over the last 20 years, the ethical questions surrounding its use have been focused within the medical community. Some evidence suggests that the delta-9 tetrahydrocannabinol (THC) chemical contained in marijuanacan provide legitimate pain relief and improved quality of life for the medically ill.

Beyond the obvious obstacle of the non-prescribed possession of marijuana being illegal in the United States, other problems lie in the fact that there is a limited cache of evidence regarding the plant’s medicinal benefits. At this nine states have laws allowing doctors to prescribe marijuana, but the Federal Drug Enforcement Agency (DEA) consistently hinders any use of the drug. It argues that the evidence is not empirical and anecdotal at best. However, if the federal government would approve further research and practitioners acted responsibly, marijuana could very soon become a viable, legal, and efficient alternative to traditional medicine.

Legalization: The Worst Case Scenario
Relatively, it’s not hard t0 imagine the consequences of legalizing Marijuana for use by the general public. Research has shown a severe “impairment of attention, learning, and memory…” (kalat et al., 2001). Drivers and workers under the influence and illegal distribution are just a few of the potential problems that come to mind. One might ask, how ethically responsible would it be for the U.S. Government to willingly authorize the use of the marijuana plant? In the research magazine, Texas Medicine, Dr. Leonides G. Cigarroa, Council Chair of the Texas Medical Association, acknowledged that little is known about the effects of tetrahydrocannabinol and fails to offer a solution for the harm done by inhaling smoke directly into the lungs.

This is quite ironic considering that there is a confounding array of legal drugs, both prescribed and over-the-counter, that present some of the same consequences as marijuana. Barbiturates, anti-depressants, and alcohol affect serotonin and dopamine levels, causing very similar physiological effects. Drugs like Amphetamines, Phencyclidine (PCP), and even Ca-ffeine, have proved more responsible for impaired memory, and hallucination. As for the smoke inhalation of marijuana, Nicotine-laden tobacco products are one of the leading, legally sold drugs in America.

Evidence: Absent or Ignored? 
It is a struggle to understand why the U.S. Drug Enforcement Agency has gone out of its way to restrict the conscientious efforts of researchers.  Noelle Davis, executive director of Texans for Medical Marijuana, points out that “the [researchers] keep being blocked or no one answers their requests for two or three years” (Ortolon, 2004, par. 21). The DEA argues that the evidence available is insufficient to authorize the medical use of the plant, but won’t even authorize any responsible, empirical study of its use. 

In 1995, it was discovered that #a chemical called anandamide, which naturally binds to cannabinoid receptors in the skin and brain.  The discovery revealed that a specific receptor chemical called ananadamide has “at least one known function, which is to decrease pain” (Kalat etal., 2001, p. 74).  In 1997 a similar discovery was made about a chemical called sn-2 arachidonytylglycerol.  The chemical inhibits serotonin synapses in the brain, which are related to severe nausea. The government should have a moral responsibilityto at least allow researchers to offer patients suffering from AIDS, Diabetes, MS, Fibromyalgia, and Cancer an alternative form of treatment?

A Note on Patient Riahts and Privacy
Another moral debate concerns the physician-patient rrelationship, and their ability to pursue all possible treatments. Presently, many state laws prevent a doctor from even conversing with their patients about the use of marijuana.  If a doctor and patient feel in jeopardy of being arrested, then neither can even asses the possible benefits of the therapy. Houston Neonatalogist, Dr. Michael Speer says, “Issues between physicians and patients ought to be issues between physicians and patients” (Ortolon,2004, par. 14).

The federal government continually exacerbates this issue by stepping on the state’s rights and laws where medicinal marijuana use is already legal. They indict users and pester the doctors who are acting within the law when prescribing the medicine. There are numerous regulatory bodies, including the Council on Scientific Affairs and the Texas Medical Association, who argue that it is a freedom of speech  and that health care providers should “be allowed to discuss any and all treatment options ……without the fear of regulatory,disciplinary, or criminal sanctions” (Ortolon, 2004, para. 12).

In The End
In the end, legislators, health care providers, and patients must agree to conduct more research.  Only open-minded dialogue can balance the hopes and fears for medicinal marijuana. Former Presidential nominee John Kerry, who has supposedly “admitted to smoking marijuana in the past …,” once promised that if elected, he would investigate the innovative research that has been conducted on medical marijuana use. (Cannabis News Staff, 2003, para. 11).

References

Cannabis News. (2004, August 6). Kerry: Get an Herbal, not a Fetal
          Position (Article 20). Retrieved October 1, 2004, from
          http://www.texmed.org/ata/nrm/tme/sept04_science_marijuana.asp

Kalat, J. W., et al., (2001). Biological Psychology. (7thed.). Belmont:
          Wadsworth and ‘Thompson Learning.

Ortolon, K. (2004, September). Lighting Up a Controversy: Debate Over
          Medical Marijuana Heats Up. In Texas Medicine Magazine. Texas
          Medical Association © 2001.   Retrieved October 01, 2004, from
          http://www.texmed.org/ata/nrm/tme/sept04~science~marijuana.asp
_____________________________________________________________________________________

Redacted  from an original research compiled by Justin E. Brown  |  Old Dominion University
Originally published: October 05, 2004





Living Bipolar – Jeckle and Hyde Explained

25 03 2008

woman-over-ocean.jpgMental Illness

By Justin Brown | 03 MARCH 2008 | Cincinnati

A couple of years ago, my mother called me to tell me that a very close relative of mine had stabbed her boyfriend over, what seemed to be, a trivial matter.  They had a regular argument over something all normal couples often do.

I was shocked and thought, “there must be more to the story”. While there was another side, it never elevated to the point of justifying her physically assaulting her mate.

Over the next year or so there were more violent episodes. Her demeanor would sometimes be jovial or generous. Then, all of a sudden, she would be sad, withdrawn, and angry. She rarely ever drank, and only took the drugs that were prescribed by her doctor.   It just didn’t make sense.

Then it hit me like a two ton Mack truck! Two years before her stabbing incident, she’d been diagnosed with Severe Bipolar Disorder. Because I didn’t know much about the disease, I never thought anymore about it.  naive I know.  Last year I began to research it on my own.

coversation-with-b.jpgAccording to the Depression and Bipolar Suppport Alliance, nearly 5.7 million adults suffer from the Jeckly-n-hyde-like disease in the U.S.[A] Taking medications, or not taking medications, can drastically affect the expression of its symptoms.   Even to the point that, “one in five patients with Bipolar Disorder completes suicide”, adds the DBSA [A].

Recently, while listening to a friend’s talk show [1], I caught a glimpse of what it’s like to have BP from a group of  her special guests.  All officially diagnosed with the disease, they described child experiences that eerily mimicked those that my own family member had exhibited growing up.

With the humor of a comedian they takled the nuances of living bipolar; the good, the bad, and the ugly. (Sorry about the worn cliche). While it would seem that the disease doesn’t yet have a complete cure, it is highly manageable with the appropriate balance of diet, medications, exercise, adn education. The National Institute of Health has continues to conduct a host of clinical trials that promise to improve the lives of those living in pain.[2]

Let us know what YOU THINK by leaving a comment below:

Additional Resources

[1] Conversations with B | Radio Talk Show Broadcast on Depression -http://www.blogtalkradio.com/conversations/2008/03/24/Conversations-with-B-Featuring-Rob-our-own-Psycologist

• Visit the host of Conversation with B’ at her MySpace.com page at:
http://profile.myspace.com/index.cfm?fuseaction=user.viewprofile&frien did=139930137&MyToken=467392cc-7885-444a-83a6-af5901bab5d1

• Also see :http://www.blogtalkradio.com/conversations

Treatment | National Institute of Health -http://www.nlm.nih.gov/medlineplus/bipolardisorder.html#cat3

[2] Clinical Trials | National Institute of Health -
http://clinicaltrials.gov/search/open/condition=%22Bipolar+Disorder%22

Coping | Track Your Mood Swings -
http://www.dbsalliance.org/pdfs/calendarforweb.pdf

Sources

[A] Depression and Bipolar Support Alliance website -
http://www.dbsalliance.org/site/PageServer?pagename=about_statistics_bipolar